孔雀石绿及其代谢物无色孔雀石绿在鲫鱼肌肉中的代谢规律

Study on Metabolism of Malachite Green in Crucian (Carassius auratus) Muscle

研究了孔雀石绿及其主要代谢物无色孔雀石绿在鲫鱼肌肉组织内的残留消除趋势。对鲫鱼以200 ng/mL浓度孔雀石绿进行药浴1 h,取肌肉采用高效液相色谱法测定孔雀石绿及代谢物无色孔雀石绿的残留状况。结果表明,孔雀石绿代谢相对较快。代谢产物无色孔雀石绿残留时间较长,可以作为检测的标志物。

The metabolism of malachite green（MG） in crucian （Carassius auratus） was studied. The uptake and depletion of malachite green in crucian muscle tissue were determined after water-borne exposure （200 ng/g, 1 h） under simulated aquaculture farming conditions by high performance liquid chromato graphy （HPLC）. The result showed that malachite green was converted to its major metabolite relatively rapidly. Leucomalachite green（LMG） was very slowly eliminated from the muscle tissue and can be used as a target analyte in residue-monitoring programs.