24小时平均脉压与冠心病的临床研究

A clinical study pulse pressure and severity of coronary artery stenosis

目的:探讨高血压患者24 h平均脉压(24 hPP)与冠状动脉狭窄的关系。方法:338例高血压(EH)患者均行动态血压(ABP)监测、冠状动脉造影及冠状动脉狭窄积分。根据24 hPP水平分为<60 mmHg组和≥60mmHg组。根据冠脉造影结果分为冠脉狭窄组和非冠脉狭窄组,比较2组的冠脉狭窄积分及狭窄率。结果:PP≥60 mmHg组的冠脉狭窄记分、冠脉狭窄率高于PP<60 mmHg组。结论:PP增大是冠心病的独立危险因素,使冠状动脉的狭窄率、狭窄程度、累及的血管支数增加。

Objective： To investigate the relationship between pulse pressure （PP） and severity of coronary artery stenosis. Methods： Three hundred and thirty-eight patients were enrolled, all the patients underwent coronary angiography and their systolic blood pressure （SBP） diastolic blood pressure （DBP） and PP were measured then the relationship between PP and severity of coronary artery stenosis was determined. According to 24 hPP and the results of coronary angiography, all the patients were repectively divided into two groups （1） the group of 24 hPP〈60 mmHg and the group of 24 hPP≥60 mmHg. （2） coronary stenosis group and normal coronary group, coronary stenosis score and the stenosis rate were compared between the two groups. Results： The degree of coronary artery stenosis in the group PP≥60 mmHg was higher than that of the normal group （P〈0.05）. Conclusion： PP levels were significantly higher in patients （P〈0.001） with coronary artery disease than that in the normal subjects.