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血管平滑肌钙激活钾通道及其在高血压发病中的功能异常 被引量:3

Calcium-activated potassium channels in artery smooth muscle and its dysfunction in hypertension
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摘要 目的:血管平滑肌大电导钙激活钾通道(BKCa)是血管平滑肌细胞膜电位的主要调控器,它调节血管张力。研究表明高血压时出现脉管张力增高及对扩张的血管的缓冲能力下降等多种病理状态与血管平滑肌BKCa功能变化有关,包括与BKCa对Ca2+火花的调节反应发生变化相关。本文综述高血压时血管平滑肌BKCa功能和结构变化的研究报道。
作者 杨艳 曾晓荣
出处 《四川生理科学杂志》 2006年第3期115-118,共4页 Sichuan Journal of Physiological Sciences
基金 国家自然科学基金资助课题NO.30370527
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参考文献24

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同被引文献49

  • 1高兰兰,冯崴,武文君,王廷涛,沙莎,王茂松,朱建.左旋氨氯地平与坎地沙坦治疗原发性高血压伴左心室肥厚临床疗效及对心率变异性的影响[J].湖南师范大学学报(医学版),2020(6):21-25. 被引量:5
  • 2林其德.子癎前期及子的病因学研究进展[J].中国实用妇科与产科杂志,2006,22(1):3-5. 被引量:29
  • 3张劲松,王健.长效钙离子拮抗剂的研究进展[J].中国误诊学杂志,2007,7(3):437-439. 被引量:12
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  • 5Benzhi Caia, Dongmei Gong a, Zhenwei Pan, et al. Large-conductance Ca^2+-activated K^+ currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells [J]. Life Sciences,2007,80(22):2060-2066.
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  • 8Ko EA, Han J, Jung ID, etal. Physiological roles of K^+ channels in vascular smooth muscle cells[J]. Smooth Muscle Res, 2008,44 (2) :65-81.
  • 9贺同强,苟文丽,李雪兰.妊娠期高血压疾病钾通道功能的改变[J].中国妇幼健康研究,2007,18(4):279-281. 被引量:9
  • 10HU Xiang-qun,ZHANG Lu-bo.Function and regulation of large conductance Ca2+-activated K+Channel in vascular smooth muscle cells[J].Drug Discovery Today,2012,17(17/18):974-987.

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