485例O型血孕妇ABO血型抗体效价的检测结果分析与新生儿溶血病的防治

Analysis of the ABO Blood Group Antibody Effect Price in 485 Case Pregnant Women of the "O" Group Blood

目的:探讨O型血孕妇孕期免疫性抗体(IgG)效价与新生儿溶血病(HDN)发病的相关性。方法:采用血型血清学方法对485例孕妇产前抗A(B)IgG检测结果进行分析,以证实产前IgG抗体效价的高低与HDN发病的关系。结果:483例O型血孕妇从孕7月进行抗体效价测定,2例从孕5月开始,其中定期进行抗体效价检测在3次以上者31例,占6.39%,ABO血型不合者中抗A(B)IgG≥1∶64者占3.09%(15/485),抗体效价的高低和HDN发病率呈正相关。结论:积极开展产前检测夫妇ABO血型不合,特别是O型孕妇的抗A(B)IgG效价,对预防和治疗ABO HDN,提高我国出生人口素质具有重要意义。

Objective： To study the relationship between the antibody titer of seriumanti - A （B） IgG and hemolytic disease of the newborn （HDN） in the ＂ O＂ type blood pregnant women. Methods： Serum analysis method of blood group was used to detect the expression of anti - A （B） of IgG in 485 pregnant women, and to confirm the relationship between the antibody titer and hemolytic disease of the newborn （HDN）. Results： We had detected the antibody titer in 483 women who have pregnanted for seven months and 2 women who have pregnanted for five months, the positive rate of antibody was 6. 39% , 31 cases among these people were detected above 3 times by dynamic monitoring. The antibody titer of serum anti - A （B） ≥1 ： 64 was 3.09% （ 15/485 ）. There is a positive relationship between the antibody titer and hemolytic disease of the newborn （HDV）. Conclusion： In order to prevent and treat the ABO HDN, It is suggested that blood type and antibody should be tested on those with blood type incompatibility before delivery.