丙氨瑞林治疗子宫内膜增生时对卵巢功能的影响

Study on effect of treating endometrial hyperplasia with alarelin on ovarian function

目的:研究丙氨瑞林治疗子宫内膜增生时对卵巢功能调节激素的影响,以及在其治疗之后卵巢功能恢复情况。方法:将子宫内膜增生患者随机分成两组:丙氨瑞林组和炔诺酮组(对照组)。采用放射免疫测定法测定两组用药前后卵泡刺激素(FSH)、黄体生成素(LH)、E2、T、P、PRL水平来评价两种药物治疗对卵巢调节激素的影响;随访药物治疗后月经恢复时间,以其作为卵巢功能恢复时间来评价两种药物治疗之后卵巢功能恢复状况。结果:(1)丙氨瑞林组用药后FSH、LH及E2均低于用药前(P<0.05);(2)炔诺酮用药后E2水平降低(P<0.05);(3)丙氨瑞林组用药后FSH、LH及T较炔诺酮组降低明显(P<0.05)。(4)丙氨瑞林组停药后卵巢功能恢复时间短于炔诺酮组(P<0.05)。结论:(1)丙氨瑞林治疗子宫内膜增生后可以降低FSH、LH及E2,而炔诺酮仅能降低E2;E2降低的水平在2组差异无统计学意义。(2)丙氨瑞林治疗组停药后卵巢功能恢复较快,优于炔诺酮组。

Objective：To study the effect of treating endometrial hyperplasia with alarelin on ovarian function to regulate hormones, and observe resumption of ovarian function after treatment. Methods ： The patients were randomly divided into an alarelin group and a norethisterone group. The radioimmunoassay （RIA） was used to determine the levels of follicle stimulating hormone （FSH） ,luteinizing hormone（LH） ,estradiol（ E2 ） ,progesterone（P） ,testosterone（T） and prolaction（PRL） before and after treatment of endometrial hyperplasia with drugs so as to evaluate the effect of the two kinds of drugs on regulation of hormones by the ovary. After treatment,a follow -up survey was made of the patients to determine the date of menstrual recovery,which was taken for the symbol of resumption of ovarian function ,according to which we could judge which of the two drugs was more favourable for protecting the ovarian function. Results ： （ 1 ） In the alarelin group,the levels of FSH, LH and E2 were lower after treatment than before treatment, with a difference of statistical significance（ P 〈 0.05 ） ;（ 2 ）In the norethisterone group, the level of E2 was lower after treatment ,there being a difference of statistical significance（ P 〈 0.05 ） ; （3）After the use of drugs,the levels of FSH ,LH and T were evidently lower in the alarelin group than in the norethisterone group,with the difference being of statistical significance （ P 〈 0.05 ）. （4） After withdrawal of alarelin,the course of resumption of ovarian function was shorter in the alarelin group than in the norethisterone group,the difference being statistically significant. Conclusion ： （ 1 ） When used to treat endometrial hyperplasia, alarelin can reduce the levels of FSH, LH and E2 ,but norethisterone can only lower the level of E2. There is no statistical difference in reduction of the level of E2 between the two groups. （2） After withdrawal in the alarelin group ,ovarian function recoyers quicker,and is better than in the norethisterone group.