期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

调节性T细胞的研究进展 被引量：4

Progress in regulatory T cells research
下载PDF
导出
摘要 调节性T细胞(regu latory T cells,T reg)是维持机体免疫平衡的功能成熟的T细胞。在体内外T reg通过抗原非特异性或特异性扩增,下调效应性免疫细胞的功能并削弱其增殖能力,来抑制或控制机体免疫应答的程度。T reg为临床疾病的免疫治疗提供了新的途径。 Regulatory T cells （Treg） are functionally mature T cell subpopulations which are key players of maintaining the balance of immunological defense system. Treg can proliferate in vivo or in vitro by antigen specific way or non-antigen specific way, and actively control the properties of other immune cells by suppressing their functional activity and their proliferation as well.
作者 蔡永君 孙文佶
机构地区 浙江大学医学院免疫研究所
出处 《浙江大学学报（医学版）》 CAS CSCD 2006年第5期568-572,共5页 Journal of Zhejiang University(Medical Sciences)
关键词 T淋巴细胞/免疫学 免疫耐受 免疫系统疾病/免疫学 T-Lymphocytes/immunol Immune tolerance Immune system diseases/immunol
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献22

  • 1SHEVACH E M.CD4+ CD25+ suppressor T cells:more questions than answers[J].Nat Rev Immunol,2002,2(6):389-400.
  • 2TAI X,COWAN M,FEIGENBAUM L,et al.CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2[J].Nat Immunol,2005,6(2):152-162.
  • 3TANG Q,HENRIKSEN K J,BODEN E K,et al.Cutting edge:CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells[J].J Immunol,2003,171(7):3 348-3 352.
  • 4HORI S,NOMURA T,SAKAGUCHI S.Control of regulatory T cell development by the transcription factor Foxp3[J].Science,2003,299(5 609):1 057-1 061.
  • 5CHOI B M,PAE H O,JEONG Y R,et al.Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression[J].Biochem Biophys Res Commun,2005,327(4):1 066-1 071.
  • 6MARIE J C,LETTERIO J J,GAVIN M,et al.TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells[J].J Exp Med,2005,201(7):1 061-1 067.
  • 7ZHENG S G,WANG J H,GRAY J D.Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity:the role of IL-2,TGF-beta,and IL-10[J].J Immunol,2004,172(9):5 213-5 221.
  • 8LEVINGS M K,GREGORI S,TRESOLDI E,et al.Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells[J].Blood,2005,105(3):1 162-1 169.
  • 9MANAVALAN J S,KIM-Schulze S,SCOTTO L,et al.Alloantigen specific CD8+CD28-FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells,inhibiting alloreac-tivity[J].Int Immunol,2004,16(8):1 055-1 068.
  • 10CAMAARA N O,SEBILLE F,LECHLER R.Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation[J].Eur J Immunol,2003,33(12):3 473-3 483.

同被引文献49

  • 1詹静,吴慧玲,冯剑颖,谷志远,刘丽,吴刚.BMP/Smads信号传导通路在兔下颌持续前导后髁突的表达[J].浙江大学学报（医学版）,2006,35(5):485-490. 被引量：7
  • 2熊国林,黄海潇,谢玲,余祖胤,王欣茹,刘耀文,邢爽,赵振虎,董波,罗庆良.类风湿性关节炎大鼠模型的制备[J].解放军医学杂志,2007,32(2):121-123. 被引量：39
  • 3陆再英,钟南山,谢毅,等.内科学[M].7版.北京:人民卫生出版社,2010:125-126.
  • 4Zhang XG,Klein B,Bataille R,et al.Interleukin-6 is a potent myeloma cell growth factor in patients with aggressive multiple myeloma[J].Blood,1989,74(1):11-17.
  • 5Beloosesky Y,Salman H,Bergman M,et al.Cytokine levels and phagocytic activity in patients with Alzheimer′s disease[J].Gerontology,2002,48(3):128-135.
  • 6Kishimoto T,Taga T,Sui XW,et al.IL-6 and it′s recepetor is a hexameric complex consisting of two molecules each of IL-6,IL-6R and gp130[J].J Biochem,1994,269(37):23286-23291.
  • 7刘健,范海霞,杨梅云.新风胶囊对类风湿性关节炎患者的疗效及肺功能生活质量的影响[J].中华中医药学刊,2007,25(10):2060-2064. 被引量：30
  • 8Pearce EN, FarweIl AP, Bravermart LE. Thyroiditis[J]. N Engl J Med,2003,48(26) :2646-2655.
  • 9Drugarin D,Negru S,Koreck A,et al. The pattern of a T(H)I ey tokine in autoimmune thyroiditis[J]. ImmunoI Lett, 2000,71 (2) 73-77.
  • 10Langrish CL, Chen Y, Blumenschein WM, et al. IL -23 drives a pathogenic T cell regulation that induees auto-immune in flare- marion[J]. J Exp Med,2005,201(2) ,233-240.

引证文献4

二级引证文献21

浙江大学学报（医学版）
2006年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部