热休克蛋白90 mRNA在大肠腺癌及腺瘤中表达的意义

Significance of expression of heat shock protein 90mRNA in large intestine adenocarcinoma and adenoma

目的:探讨HSP90 mRNA在大肠腺癌发生中的意义。方法:利用核酸原位杂交技术,对69例大肠腺癌及26例大肠黏膜慢性炎和16例腺瘤标本中HSP90 mRNA进行检测。结果:HSP90 mRNA在大肠黏膜慢性炎中有极低表达率3.8%(1/26),在腺瘤中阳性率为43.8%(7/16),在大肠腺癌中阳性率为69.6%(48/69)。HSP90 mRNA的表达与大肠腺癌病理类型、分化程度和淋巴结转移有相关性。结论:HSP90 mRNA高表达与大肠腺癌的发生、发展有关。

Objective：To study the significance of expression of heat shock protein 90 mRNA（ HSP90 mRNA） in large intestine adenocarcinoma. Methods：The expression of HSP90 mRNA was examinated by in situ hybridization （ISH） in 69 cases of large intestine adenocarcinoma,26 cases of chronic mucositis of large intestine and 16 cases of adenoma. Results： The positive rate of HSP90 mRNA expression was 69.6% （48/69） for large intestine adenocarcinoma, 43.8% （7/16） for adenoma, and as low as 3.8% （1/26） in chronic mucositis of large intestine. The expression of HSP90 mRNA was correlated with the pathologic type, differentiation degree and lymph node metastasis of large intestine adenocarcinoma. Conclusion：The expression of HSP90 mRNA is high in large intestine adenocarcinoma and is related to the onset and development of large intestine adenocarcinoma.