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低氧诱导因子-1在软骨代谢中的作用及其机制 被引量：4

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作者 任步方 邓廉夫
机构地区 上海市伤骨科研究所
出处 《中华骨科杂志》 CAS CSCD 北大核心 2006年第9期630-632,共3页 Chinese Journal of Orthopaedics
基金 上海市科委重点实验室开放基金(040DZ5606)
关键词 低氧诱导因子-1 软骨代谢 20世纪90年代 效应基因 癌症防治 内环境稳定 生物学行为 HIF
分类号 R68 [医药卫生—骨科学]
  • 相关文献

参考文献22

  • 1Henrotin Y,Kurz B,Aigner T.Oxygen and reactive oxygen species in cartilage degradation:friends or foes? Osteoarthritis Cartilage,2005,13:643-654.
  • 2Grimshaw MJ,Mason RM.Bovine articular chondrocyte function in vitro depends upon oxygen tension.Osteoarthritis Cartilage,2000,8:386-392.
  • 3James MJ,Cleland LG,Rofe AM,et al.Intraarticular pressure and the relationship between synovial perfusion and metabolic demand.J Rheumatol,1990,17:521-527.
  • 4Lee RB,Urban JP.Evidence for a negative Pasteur effect in articular cartilage.Biochem J,1997,321(Pt 1):95-102.
  • 5Malda J,Martens DE,Tramper J,et al.Cartilage tissue engineering:controver-sy in the effect of oxygen.Crit Rev Biotechnol,2003,23:175-194.
  • 6Stockwell RA,ed.Metabolism of cartilage.In:Hall BK,ed.Cartilage:structure,function and biochemistry.1st ed.New York:Academic Press,1983.253-280.
  • 7Johnson K,Jung A,Murphy A,et al.Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization.Arthritis Rheum,2004,3:1560-1570.
  • 8Bunn HF,Poyton RO.Oxygen sensing and molecular adaptation to hypoxia.Physiol Rev,1996,76:839-885.
  • 9Carmeliet P,Dor Y,Herbert JM,et al.Role of HIF-1 alpha in hypoxia-mediated apoptosis,cell proliferation and tumour angiogenesis.Nature,1998,394:485-490.
  • 10Schipani E,Ryan HE,Didrickson S,et al.Hypoxia in cartilage:HIF-1 alpha is essential for chondrocyte growth arrest and survival.Genes Dev,2001,15:2865-2876.

同被引文献83

  • 1刘晓东,邓廉夫.骨系细胞的低氧感应及其机制[J].中华骨科杂志,2007,27(2):138-141. 被引量：4
  • 2Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage, 2005,13: 643-654.
  • 3Behrooz A, lsmail-Beigi F. Stimulation of glucose transport by hypoxia: signals and mechanisms. News Physiol Sci, 1999, 14:105-110.
  • 4Ismail-Beigi F. Metabolic regulation of glucose transport. J Membr Biol, 1993, 135: 1-10.
  • 5Mobasheri A, Vannucci SJ, Bondy CA, et al. Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis. Histol Histopathol, 2002, 17: 1239-1267.
  • 65 Richardson S, Neama G, Phillips T, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by 1GF-1 and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage, 2003,11: 92-101.
  • 7Kelley KM, Johnson TR, llan J, et al. Glucose regulation of the IGF response system in chondrocytes: induction of an IGF-I-resistant state. Am J Physiol, 1999, 276(4 Pt 2): R 1164-1171.
  • 8Shikhman AR, Kuhn K, Alaaeddine N. et al. N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes. J Immunol, 2001,166: 5155-5160.
  • 9Rumsey SC, Kwon O, Xu GW, et al. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem, 1997, 272: 18982-18989.
  • 10Domm C, Schunke M, Christsen K, et al. Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage, 2002, 10: 13-22.

引证文献4

二级引证文献14

中华骨科杂志
2006年 第9期

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