吲哒帕胺对高血压病患者心功能康复的影响

Effect of Indapamide on the Rehabilitation of Cardiac Function in Patients with Primary Hypertension Disease

目的探讨吲哒帕胺对高血压病患者的疗效及对心功能的影响。方法56例高血压病患者随机分为氢氯噻嗪组和吲哒帕胺组,分别应用氢氯噻嗪和吲哒帕胺治疗,并辅以合理膳食、控制体重等常规非药物治疗;治疗前与治疗2个月后采用超声心动图评定两组患者的心功能。结果治疗后,两组患者的射血分数提高,左心室相对厚度下降(P<0.05),但吲哒帕胺组的效果优于氢氯噻嗪组(P<0.05)。结论吲达帕胺改善心脏功能与结构的效果优于氢氯噻嗪。

Objective To observe the effect of Indapamide on the rehabilitation of cardiac function in patients with primary hypertension disease. Methods 56 patients with primary hypertension disease were randomly divided into the Indapamide group and Hydrochlorothiazide group with 28 cases in each group, and treated with Indapamide and Hydrochlorothiazide respectively assisted with conventional non-drug treatment such as dietetic and weight control. The cardiac functions of patients in two groups were examined with echocardiography before and two months after treatment. Results After treatment, the left ventricular ejection fraction （LVEF） raised and relative wall thickness （RWT） declined in patients of two groups, that of the Hydrochlorothiazide group （P 〈0.05）. Conclusion The effect of than Hydrochlorot hiazide.