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大鼠海马突起坍塌蛋白Sema3A及其受体neuropilin-1 mRNA的表达 被引量：1

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摘要 目的探讨大鼠海马Sema3A及其受体neuropilin-1(NP-1)mRNA在发育过程中表达的规律。方法采用RT-PCR方法检测大鼠海马发育不同阶段Sema3A及其受体NP-1 mRNA的表达。结果Sema3A电泳条带灰度呈下降趋势,在胚胎期、新生期有较高的表达,幼年期、成年期和老年期表达较弱。NP-1电泳条带在大鼠海马发育的各个时期均有较高的表达,以胚胎期最高,新生期表达相对其他时期弱,但在幼年期、成年期和老年维持较高表达水平。结论大鼠海马在胚胎期和新生期是非目的性突起坍塌的活跃期,幼年、成年和老年期处于相对休眠期;NP-1始终处于高表达状态,可能参与神经退行性疾病的发生。
作者 郭国庆 陈静 辛莉 沈伟哉 邱小忠 钟世镇
机构地区 南方医科大学临床解剖学研究所生物力学实验室 暨南大学医学院解剖学教研室
出处 《广东医学》 CAS CSCD 北大核心 2006年第10期1444-1446,共3页 Guangdong Medical Journal
基金 广东省自然科学基金团队项目(编号:039213) 广州市科技局科技计划项目(编号:2004J1-C0214)
关键词 SEMA3A NEUROPILIN-1 海马 发育 大鼠
分类号 R733.71 [医药卫生—肿瘤]
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参考文献7

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共引文献2

同被引文献14

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广东医学
2006年 第10期

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