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鞘内咪唑安定复合芬太尼改善腰麻的质量 被引量:1

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摘要 目的探讨鞘内咪唑安定及复合用药的临床应用价值。方法择期L(4—5)或L5S1椎间盘髓核摘除手术患者60例,术前ASA1~2级,全部患者采用腰麻手术。手术前患者随机等分为4组:B组鞘内注入0,75%布比卡因2ml(15m异);M组腰麻前鞘内注入力月西1.5mg;F组腰麻前注入芬太尼15μg;MF组腰麻前注入力月西1.5mg+芬太尼15μg。腰麻平卧后测试麻醉阻滞上升平面,术中观察麻醉效果及镇静情况,术后随防24h疼痛、镇痛用药、恢复情况及其他反应,围术期持续监测呼吸、循环状态。结果4组患者顺利完成手术,B组患者60%镇静0分,40%镇静1分,M和F组患者镇静均为1分,MF组患者66.7%镇静评分为2分,33.3%为1分;麻醉平面上升速度及运动阻滞F组快于MF组,MF组快于M和B组(P〈0.05~0.01),与B组对照,M,F及MF组术后第一疼痛时间明显延长(P〈0.05~0.01),MF组时间最长(P〈0.05);B和M组内12h点VAS评分较高(P〈0,05);F组内及与B组间比较,24h点VAS评分较低(P〈0.05);与B组比较,MF组VAS评分在术后4,8,12,24h时间点均较低(P〈0.05);术后肌肉注射曲马多百分比为B组73.3%,M组60.0%,F组53.3%,MF组33.3%,MF组用药最少(P〈0.05)。结论鞘内咪唑安定1.5mg可以改善腰麻的效应,显示术中患者安静合作,延长术后镇痛时间,然而复合芬太尼15μg更加明显改善腰麻质量,表现良好术中镇静,延长术后镇痛时间、且术后疼痛轻、镇痛用药减少.无明显副作用。
出处 《广东医学》 CAS CSCD 北大核心 2006年第10期1480-1481,共2页 Guangdong Medical Journal
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