2[1]P.A.Steck,M.A.Pershous,S.A.Jasser, et al. Tavtigian,Identification of a candidate tumor suppressor gene, MMAC1 ,at chromosome 10q23.3 that is mutated in multiple advanced cancer[J].Nat Genet, 1997,15:356- 362.
3[2]M.Tamura,J.Gu,K. Matsumoto,et al. Inhibition of cell mi gration,spreading, and focal adhesions by tumor suppressor PTEN[J]. Science , 1998,280:1614 - 1617
4[3]Kantor JO, Mc Cormick B, Steeg PS, et al. Inhibition of cell motility after nm 23 transfection of human and murine tumor cells[J]. Cancer Res, 1993,53: 1 97.
5[4]Carolyn M, Cover S, Jean Hsieh, Susan H Tran, et al. In dole- 3 - carbinol Inhibits the Expression of Cyclin- de pendent Kinase - 6 and Induces a G1 Cell Cycle Arrest of Human Breast Cancer Cells Independent of Estrogen Recep tor Signaling[J]. J Biol Chem, 1998, 273: 3838- 3847
6[5]Masahito Tamura, Jianguo Gu, Takahisa Takino. et al .Tumor Suppressor PTEN Inhibition of Cell Invasion, Migration, and Growth: Differential Involvement of Focal Adhesion Kinase and p130cas[J]. Cancer Research, 1999,59:442 - 449
7[6]Cantley LC, Neel BG. New insights into tumor suppression:PTEN suppresses tumor formation by restraining the phosphoincsiade 3 - kinase/Akt pathway[J]. Proc Natl AcadSci USA, 1999, 90:4240-4245
8[7]Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt -dependent cell survival by the tumor suppressor PTEN[J]. Cell, 1998, 95(1): 29- 39
9Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW.Negative regulation of PKB/Akt-dependent cell survival bythe tumor suppressor PTEN. Cell 1998; 95:29-39.
10Cheney IW, Johnson DE, Vaillancourt MT, Avanzini J,Morimoto A, Demers GW, Wills KN, Shabram PW, Bolen JB,Tavtigian SV, Bookstein R. Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res 1998; 58:2331-2334.
3Hariu H,Hirohashi Y,Torigoe T,et al.Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family,Livin/ML-IAP in lung cancer.Clin Cancer Res,2005,11(3):1000-1009.
4Tanabe H,Yagihashi A,Tsuji N,et al.Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer,Lung Cancer,2004,46(3):299-304.
5Wang MY,Lu KV,Zhu S,et al.Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase lnhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells.Cancer Res,2006,66(16):7864-7869.