血管紧张素转化酶基因多态性与肝硬化发生的研究

Relation between polymorphism of angiotensin-converting enzyme gene and liver cirrhosis

目的探讨ACE基因的多态性与肝硬化发生的关系。方法比较193例肝硬化患者和219例健康人D/I基因型的分布情况,用PCR直接分型法检测ACE基因多态性。结果219例健康对照中,DD型占21.0%,II型占29.2%,DI型占49.8%。193例肝硬化患者中DD型占15.5%,II型占38.3%,DI型占46.1%。两组间基因型分布差异无显著性。但肝硬化患者中I等位基因频率显著高于健康对照(P<0.05)。结论I等位基因可能与肝硬化发生有关。

[Objective] To study the relationship between the development of liver cirrhosis and the genotype of ACE. [Methods] 193 cases of patients with liver cirrhosis and 219 cases of control were selected and were determined genotype of ACE by polymerase chain reaction （PCR）. [Result] Among the control group, Genotype DD, Ⅱ and DI were respectively 21.0%, 29.2% and 49.8%; while among the patients with liver cirrhosis, they were 15.5%, 38.3% and 46.1%. There was no significant difference in genotype distribution between the two groups. Ⅰ allele frequencies in patients with liver cirrhosis were more than that of the control. [Conclusion] Ⅰ allele site is prone to develop liver cirrhosis.