肺癌患者治疗前后血清白细胞介素-6、肿瘤坏死因子和血管内皮生长因子水平及其临床意义

Clinical significance of determination of changes of serum IL-6,TNF and VEGF levels after treatment in patients with lung cancer

目的探讨肺癌患者治疗前后血清IL-6、TNF、VEGF水平的变化及临床意义。方法采用酶联免疫吸附法和放射免疫分析法分别测定了98例肺癌患者血清IL-6、TNF、VEGF含量水平,并与60例正常健康人作比较。结果化疗前肺癌患者血清IL-6、TNF、VEGF含量水平均显著地高于正常人(P<0.01)。结论测定肺癌患者血清IL-6、TNF、VEGF水平,对其病情了解、疗效观察、判断预后都具有极其重要的临床价值。

[Objective] To detect the clinical significance of changes of serum IL-6, TNF and VEGF levels after treatment in 98 patients with lung cancer. [Methods] Serum IL-6, TNF（with RIA） and VEGF （with ELISA） contents were determined both before and after treatment in 76 patients with lung cancer as well as in 60 controls. [Results] Before treatment, serum IL-6, TNF and VEGF levels in the patients were significantly higher than those in the controis （P 〈0.01）. [Conclusion] The changes of levels of serum IL-6, TNF and VEGF were closely related to the disease status and was of prognostic value in lung cancer.