辽宁地区1 295例肾活检病理分析

Analysis of 1 259 renal biopsy data in Liaoning area

目的回顾总结该院肾活检穿刺的标本,了解辽宁地区肾脏病的临床表现,病理类型和流行病学特点。方法对1997年5月～2004年12月在该科行肾活检的1295例肾脏病患者的性别、年龄、病理类型及临床表现等进行分析。结果肾小球疾病仍占该组病例的绝大多数,其中原发性肾小球肾炎(PGN)占76.4%,继发性肾小球肾炎(SGN)占19.0%,间质性肾病3.4%,肾移植相关的肾脏疾病占0.7%。PGN中男女发病率之比1.49∶1,SGN中男女发病之比为1∶1.51。两者高发年龄均为15～44岁。结论辽宁地区肾脏病病理类型中系膜增生性肾小球肾炎、局灶节段性肾小球硬化和IgAN是最常见的PGN;狼疮性肾炎和紫癜性肾炎是最常见的SGN。PGN男性发病率高,SGN中女性发病率高。

[Objective] To investigate the clinical features, pathology type and epidemiology trait of renal diseases in Liaoning, China. [Methods] The data of 1 295 paitients including sex, age, pathology type, clinical features were reviewed retrospectively, and all the patients had been examined by renal biopsy in our hospital from May 1997 to December 2004. [Results] Among the 1 295 patients, primary glomerular diseases （PGN） is of the most frequent type （76.4%）, followed by secondary glomerular diseases （SGN, 19.0%）, interstitial nephritis （3.4%） and transplant nephropathy （0.7%）. In patients with PGN, the male to female ratio is 1.49：1, while in SGN it is 1：1.51. The difference beween the two groups in male to female ratio is significant （P 〈0.01）. Patients aged 15-44 accounted for the highest percentage both in PGN and SGN. [Conclusions] Among PGN, MsPGN is the most frequent pathology type, followed by FSGS and IgAN. Lupus nephritis （LN） was the most common form of SGN. Male patients predominate in PGN and female in SGN.