朗格汉斯细胞在神经性皮炎组织中的分布和CD40分子表达

The distribution of Langerhans' cells and the expression of CD40 in the tissues of neurodermatitis with its underlying significance

通过分析神经性皮炎组织病理变化、炎性细胞浸润、朗格汉斯细胞(LC)的分布以及CD40分子的表达,探讨这些变化与临床分型及病程的相关性。应用常规病理切片分析以及免疫组化的方法,观察LC和CD40分子在不同病期和炎症浸润程度皮损中的分布和表达情况。结果显示神经性皮炎组织呈现慢性炎症反应,炎症细胞的浸润,LC向真皮迁移以及CD40分子表达增加,这些均与疾病严重程度相关。基此表明LC分布的改变和CD40分子的表达与神经性皮炎免疫病理变化有密切的相关性。

The expression of CD40 , the infiltration of inflammatory cells and the distribution of Langerhans＇ cells in the skin of neurodermatitis patients was investigated by analyzing the distribution of Langerhans＇ cells and CD40 expression in injured skins of different degrees of inflammatory, infiltration at different stages of the disease by immunohistochemical mathod . Our result showed that the tissues of neurodermatitis witnessed chronic inflammatory reactions, including infihration of inflammatory cells, migration of Langerhans＇ cells to dermis and up-expression of CD40, all of which correlated to the seriousness of the disease. In conclusion the distribution of I.angerhans＇ cells and expression of CD40 have a close relationship with pathological injury in neurodermatitis.