栝楼皮注射液改善老年高血压患者生活质量和血压的观察

Effect of Gualoupi injection(栝楼皮注射液) on improvement of quality of life and blood pressure in elderly patients with hypertension.

目的:评价栝楼皮注射液对老年高血压患者生活质量和血压的影响。方法:将38例老年高血压患者按随机数字表法分成两组,对照组(18例)采用常规降压等治疗,治疗组(20例)在对照组的基础上加用栝楼皮注射液12 m l加入质量分数为5%的葡萄糖中静脉滴注,每日1次,治疗2周。观察两组治疗后患者临床证候改善情况及治疗前后24 h动态血压的变化。结果:治疗组患者临床证候中胸闷、便秘改善均明显优于对照组(P均<0.05);两组治疗后24 h动态血压均呈一致性显著下降,且治疗组夜间收缩压降低较明显(P<0.05);治疗组总有效率为85.0%,对照组为61.1%,差异有显著性(P<0.05)。结论:栝楼皮注射液与西药联合治疗老年高血压,有改善患者生活质量、辅助降低血压的效果,且未见不良反应。

Objective： To observe the clinical effect of Gualoupi injection （栝楼皮注射液） on quality of life （QOF） and blood pressure in the elderly patients with hypertension. Methods： Thirty-eight elderly patients with hypertension were randomly divided into treatment group （n= 20, routine treatment＋Gualoupi injection 12 ml in 5% glucose once a day for 2 weeks, intravenous drip） and control group （n=18, routine treatment only）. Changes of 24 hours dynamic blood pressure and improvement of clinical symptoms before and after treatment were observed. Results： In respect of ameliorating QOF, chest distress, and constipation in treatment group were superior to those of control group （both P〈0.05）, the markedly total effective rate in treatment group （85.0%） was higher than that in control group （61.1%, P〈0.05）, 24 hours dynamic blood pressure was significantly lower after treatment in two groups especially nocturnal systolic pressure in treatment group showing statistical significance in comparing the levels before treatment （P 〈0.05 ）. Conclusion： Gualoupi injection can safely and effectively lower blood pressure of elderly patients with hypertension, improve clinical symptoms and raise QOF. There is not obviously harmful reactions.