肺炎衣原体感染与高血压关系的血清流行病学研究

Sero-epidemiologic study on the relationship between Chlamydia pneumonia infection and hypertension in Chinese Mongolian population

目的探讨肺炎衣原体(CP)感染与高血压的关系以及与高血压的传统危险因素的交互作用对高血压的影响。方法选取内蒙古自治区14个村蒙古族居民1430人,其中高血压患者488例,非高血压者942人。采用ELISA法检测血清中的特异性CP IgG抗体。应用SPSS 13．0软件进行统计分析。结果高血压组和非高血压组间,CP IgG阳性率的分布差异有统计学意义,但调整年龄、性别、饮酒、吸烟、BMI和血脂异常后,这种显著性关联不存在;研究发现CP感染和性别、超重、血脂异常的交互作用与蒙古族高血压有关联,其OR值分别为13．916、5．785和2．935。结论CP感染与蒙古族高血压无关联,但与高血压的其他传统危险因素有交互作用,可使蒙古族人群患高血压的危险性增加。

Objective To explore the relationship between Chlamydia pneumonia （CP） infection and hypertension as well as the interaction of traditional risk factors and CP infections on hypertension in Chinese Mongolian population. Methods 1430 inhabitants living in Tongliao city, Inner Mongolia were selected as research subjects, including 488 hypertensives and 942 normotensives. Enzyme-linked immunoassay technique was used to test CP IgG antibody in the blood serum and SPSS 13.0 Microsoft was used to analyze the data. Results The prevalence rates of hypertension were significantly different between CP IgG positive and negative groups, However, the trend was attenuated after adjusting age, sex, drinking, smoking, body mass index （BMI） and dyslipidemia. The CP infection rate was significant different in diastolic blood pressure groups, which was significantly higher in 80-84 mm Hg than that in the lowest DBP group. The interaction of chronic CP infection and other traditional risk factors were associated with hypertension in Chinese Mongolian ethnic groups. The ranking with significant sequence from high to low were BMI, dyslipidemia, alcohol intake, sex and age. Conclusion CP infection was not related to hypertension in Chinese Mongolian ethnic groups but the interaction with other traditional risk factors would increase the risk of developing hypertension.