老年高血压颈动脉硬化尿微量白蛋白与中医证型关系的研究

Study on Correlation between TCM Differentiation and Urinary Micropeotion of Carotid Arterial Atherosclerosis in Aged Patients with Essential Hypertension

为研究老年高血压颈动脉硬化尿微量白蛋白与血瘀、痰瘀互结的关系,将60例高血压颈动脉硬化患者分为血瘀组、痰瘀组,用超声波检测颈动脉中层内膜厚度(IMT),并用放射免疫法测定尿β2微球蛋白(β2-MG)、尿微量白蛋白(Alb)、尿转铁蛋白(TRU),分析老年高血压颈动脉硬化及尿微量白蛋白与血瘀、痰瘀的关系,结果痰瘀组尿β2微球蛋白、尿微球蛋白、尿转铁蛋白升高显著,说明老年高血压颈动脉硬化与尿微量白蛋白变化有密切关系,高血压肾病早期改变以痰瘀互结为主。

To explore the correlation between blood stasis, phlegm-stasis of TCM differentiation and the changes of urinary microprotein of carotid arterial atherosclerosis in aged patients with essential hypertention. Sixty cases were divided into blood stasis group and phlegm-stasis group. The internal medial thickness were computed by colour echocardiography, the urinary β2-microglobulin, microalbumin, and trans-ferrin expression were detected by radio-immunity for studying the correlation between blood stasis, phlegm-stasis and the changes of urinary icroprotein of carotid arterial atherosclerosis in aged patients with essential hypertention. The results showed that the β2-microglobulin, microalbumin, and trans-ferrin expression of phlegm-stasis group is higher than that of blood stasis group. Conclusion： There is close relationship between the change of urinary microprotein and carotid arterial atherosclerosis in aged patients with essential hypertention, and phlegm-stasis is dominant in earlier period of hypertensive nephropathy.