血浆M2-PK的检测对胃癌的诊断价值

Diagnosis Value of Detecting Plasm Pyruvate Kinase M2 (M2-PK) in Patients with Gastric Cancer

目的探讨血浆M 2-丙酮酸激酶(pyruvate k inaseM 2,M 2-PK)含量变化与胃癌发生的关系及M 2-PK对胃癌的诊断价值。方法采用EL ISA法检测55例正常人、50例胃癌患者、45例急慢性胃炎以及42例胃良性肿瘤患者血浆M 2-PK和血清癌抗原199(CA 199)含量,进行比较。结果胃癌组血浆M 2-PK和血清CA 199含量及阳性率明显高于对照组、急慢性胃炎组及胃良性肿瘤组(P<0.01);胃癌组血浆M 2-PK和血清CA 199含量比较差异无显著性(P>0.05),阳性率比较差异有显著性(P<0.01);正常对照组、急慢性胃炎组及胃良性肿瘤组,血浆M 2-PK、血清CA 199含量及阳性率组间比较差异均无显著性(P>0.05)。结论M 2-PK是检测胃癌较为敏感的肿瘤标志物。M 2-PK的敏感性高于CA 199,具有广泛的临床应用价值。

Objectve To explore the relationship between the change of M2-PK level in plasm with the occurrence of gastric cancer and the diagnostic value for gastric cancer. Methods Plasm M2-PK and serum CA19-9 level were determined by using ELISA method in 55 normal persons,50 patients with gastric cancer,45 patients with acute gastritis or chronic gastritis and 42 patients with gastric benign tumors. Result The plasm M2-PK and serumCA19-9 level and positive rate in gastric cancer group were significantly higher than that in normal control group ,acute gastritis or chronic gastritis group and gastric benign tumor group （P〈0.01）. Significant difference of plasm M2-PK and serum CA19-9 level in gastric cancer group did not exist （P〉0. 05）,but the comparison of positive rate showed obvious difference （P〈0.01）. The comparison of plasm M2-PK and serum CA19-9 level and positive rate among normal control group,acute gastritis or chronic gastritis group and gastric benign tumor group did not show maked difference（P〉0. 05）. Conclusion M2-PK has significantly higher sensitivity than CA19-9. It is considered to be better sensitive tumor marker,and has widespread clinical practice value.