系统性红斑狼疮患者可溶性血管内皮细胞蛋白C受体的检测及临床意义

Detection of Soluble Endothelial Cell Protein C Receptor (sECPCR) in Patients with Systemic Lupus Erythematosus (SLE) and to Evaluate the Clinical Significance

目的检测系统性红斑狼疮(SLE)患者及健康人血浆中的可溶性血管内皮细胞蛋白C受体(sECPCR)水平,通过统计分析,探讨sECPCR在SLE患者中的变化及临床意义。方法利用酶联免疫双抗体夹心法(EL ISA)测定48例SLE患者及20例正常对照(NC)组血浆中的sECPCR水平。结果SLE患者与NC组的sECPCR水平比较有显著性差异(P<0.001);SLE合并血栓及无血栓患者血浆的sECPCR水平均高于NC组(P<0.005,P<0.001),且SLE并发血栓的sECPCR水平及SLE无血栓患者的sECPCR水平无显著性差异(P>0.05);SLE尿蛋白阳性与SLE尿蛋白阴性的sECPCR水平均高于NC组(P<0.001,P<0.005),SLE尿蛋白阳性的sECPCR水平高于SLE尿蛋白阴性的sECPCR水平(P<0.005)。结论sECPCR与SLE患者发生血栓无直接关系,可能参与SLE患者的炎症反应过程,其水平与炎症的发生、发展有关。

Objective To detect the level of sECPCR in 48 patients with SLE and 20 normal control （NC） for evaluating the expressing condition of sECPCR in plasma and the clinical significance. Methods An ELISA of antibody-sandwiched principle was used to detect sECPCR. Results There was significant difference between the level of sECPCR in patients with SLE and NC group（P〈0. 001）; The level of sECPCR in patients with SLE both thrombosis and no thrombosis were higher than NC group （P〈0.005,P〈0. 001）, and there was no significant difference between the two groups （P〉0. 05）, the level of sECPCR in patients with SLE of positive urine protein and negative urine protein were both higher than NC group （P〈0. 001,P〈0. 005）, and the level of sECPCR in patients with SLE of positive urine protein was higher than negative urine protein （P〈0. 005）. Conclusion sECPCR is not obvious associated with the thrombosis in patients with SLE, but it related to the process of inflammatory reaction, and reflects the progress of the disease.