卡维地络对不稳定型心绞痛血管内皮功能的影响

Effects of carvedilol on endothelium vasoactive substances in patients with unstable angina

目的观察卡维地络对不稳定型心绞痛(UAP)患者内皮素(ET)、一氧化氮(NO)、降钙素基因相关肽(CGRP)的影响。方法74例UAP患者随机分为常规治疗组34例、卡维地络治疗组40例,20例健康体检者作为正常对照组,观察用药前后血ET、NO和CGRP浓度的变化。结果UAP患者NO和CGRP浓度明显低于正常对照组(P<0·01),而ET浓度明显高于正常对照组(P<0·01)。卡维地络组患者用药后与常规治疗组比较,ET水平降低,NO和CGRP水平升高,差异有统计学意义(P<0·01)。常规治疗组与卡维地络治疗组治疗后血NO、CGRP浓度均较治疗前显著升高(P<0·01),常规治疗组治疗前后血ET浓度无显著性变化(P>0·05),而卡维地络治疗组血ET浓度显著下降(P<0·01)。结论卡维地络能改善不稳定型心绞痛的内皮功能。

Objective To observe the effect of carvedilol on circulating levels of endothelin （ET） and nitric oxide （NO） and Calcitonin gene-related peptide （CGRP） in patients with unstable angina pectoris（UAP）.Methods 74 patients with UAP were randomly divided into two groups：normal treatment group （n=34） and carvedilol group （n = 40）,20 heathy individuals were control groups. Before and after treatment, the circulating levels of ET.NO and CGRP were observed in patients with UAP and healthy individuals. Results The levels of circulating NO and CGRP in patients with UAP were significantly lower than healthy individuals （ P 〈 0.01） while the level of circulating ET was higher than healthy individuals （ P 〈 0.01 ）. After treatment the level of circulating ET in carvedilol group was lower than normal treatment group while the levels of circulating NO and CGRP level were higher than normal treatment group （ P 〈 0.01 ）. Both of two groups, the levels of circulating NO and CGRP were significantly higher than those before treatment （ P 〈 0.01） .There was no obvious lowness in the levels of circulating ET after normal treatment （ P 〉 0.05） execpt after earvedilol treatment （ P 〈 0.01 ）. Conclusion Carvedilol can do well to the endothelial function in patients with unstable angina.