神经元细胞周期再进入的研究进展

Recent Progress in Research on Reentry of Neurons into the Cell Cycle

过去一直认为神经元处于一种有丝分裂后的终末分化状态,但最近有许多资料表明成熟神经元可以重新进入细胞周期。然而,神经元的细胞周期激活机制尚不清楚。对于神经元而言,细胞周期机制是应对DNA损伤的一个重要组成部分,再进入细胞周期是为了修复DNA损伤,如损伤太重无法修复则诱导细胞凋亡。

It has been considered that neurons were in a state of terminal differentiation after postmitosis. Recently, however, many data have suggested that the mature neurons may reentry into the cell cycle. Nevertheless, the mechanism of neuronal cell cycle activation remains unclear. The mechanism of cell cycle is an important part in coping with DNA damage in neurons, and the reentry into the cell cycle is to repair the DNA damage. When the damage is too severe to be repaired, it may induce apoptosis.