黄芪对兔脑缺血再灌注损伤的影响

Effect of Radix Astragali Extract on Cerebal Ischemic - postischemic Reperfusion Injury in Rabbits

用四血管夹闭模型法建立家兔脑缺血再灌注损伤模型。在缺血前静注黄芪(3.3g/kg)可显著抑制再灌注损伤后脑组织丙二醛含量的升高(p<0.05),并提高谷胱苷肽过氧化物酶活性(p<0.05),但对再灌注损伤后脑组织钙、血栓素A_2、前列环素及环-磷酸腺苷含量无明显影响(p>0.05)。提示黄芪抗脑缺血再灌注损伤的机理与其抑制脑组织局部自由基导致的脂质过氧化损伤、提高抗氧化酶活性有关。

Acute cerebral ischemic - postischemic reperfusion injury in rabbits were made by ligaturing four arteries for 30 minuts followed by reperfution 45 minutes. Astragalus root extract (3.3g/Kg)were injected intravenously before inchemia in rabbits, it could inhibite markedly the increase of Malondial dehydee contents in brain tissue after reperfusion injuty in rabbits ( p < 0.05), could raise significanty the lowed glutathion peroxidase activities in brain tis-sue( p < 0.05 ) , but it had no effect on the calcium contents, thromboxane A2, prostacyclin and adenosine cyclic monophosphate in brain tissue (p > 0.05) .These results suggested that mechanism of Astragalus root extract on cerebral ischemic - postischemic reperfution injury was related to inhibiting lipid peroxide reaction and raising antioxidase activites in brain tissue.