心脏射频消融后心肌生化标志物的变化

The Changes of Cardiac Biochemical Markers after Radiofrequency Catheter Ablation

目的观察射频消融术后心脏肌钙蛋白(cTNI)、肌酸磷酸激酶同工酶(CK-MB)及肌红蛋白(MYO)的变化。方法测定20例阵发性室上性心动过速患者行心内电生理检查及射频消融术前及术后1、3、24小时的cTNI值、CK-MB值及MYO值,并观察三者的变化。结果术后1小时MYO较术前明显升高,其升高持续至术后3小时,术后24小时基本降至术前水平;术后1小时cTNI值无明显变化,术后3小时明显升高,且持续至术后24小时;术后3小时及24小时的CK-MB值较术前升高。结论心内电生理检查及射频消融术增加心肌生化标志物的释放;MYO早期增高,CK-MB及cTNI术后3小时升高,cTNI持续时间长。

Objective To investigate the cardiac biochemical markers changes after radiofrequency catheter ablation （RFCA）. Methods Study included 20 patients of paroxysmal supraventrictdar tachycardia who received electrophysiology study （EPS） and RFCA. Prior to ablation and 1, 3 and 24 hours following the procedure, serial blood samples were taken for measureing plasma cTNI, CK-MB and MYO concentration. Results In 20 patients subjected to EPS and RFCA, the level of MYO was found obviously elevated one hour following the procedure and kept elevated level until 3 hours. 24 hous after the procedure, MYO level returned to that prior to ablation, cTNI level was not elevated 1 hour after the procedure, it was obviously elevated 3hours after the ablation and continuously kept elevated until 24 hours. CK-MB level was found elevated at 3 and 24 hours following the procedure. Conclusions EPS and RFCA stimulate the secretion of cardiac biochemical markers, such as MYO, cTNI and CK-MB. MYO was found obviously elevated in the early stage, cTNI and CK-MB were elevated 3 hotu,s after the procedure, and cTNI kept elevated for a long time.