期刊文献+

阿托伐他汀对急性冠状动脉综合征炎症及血小板因子的影响 被引量:1

下载PDF
导出
摘要 目的探讨阿托伐他汀早期强化治疗7天后对急性冠状动脉综合征(ACS)患者高敏C反应蛋白(hs-CRP)、血小板α颗粒膜糖蛋白(CD62p)、血小板溶酶体膜糖蛋白(CD63)、血脂的影响。方法将85例ACS患者随机分为阿托伐他汀治疗组(n=45)和常规治疗组(n=40)。治疗组在常规治疗的基础上加用阿托伐他汀20mg/d每晚睡前口服,连用7天,在治疗前和治疗后分别测定hs-CRP、CD62p、CD63、血脂,并和常规治疗组进行比较。结果阿托伐他汀治疗组治疗7天后hs-CRP、CD62p、CD63均较治疗前明显下降(P<0.05);而常规治疗组治疗前后上述测定值无显著性差异;阿托伐他汀组治疗7天前后血脂指标未见明显改变(P>0.05)。结论ACS患者早期即予以阿托伐他汀强化干预,能明显减轻炎症反应,抗血小板活化,改善内皮功能,从而可以达到稳定斑块的作用。
机构地区 嘉兴市第一医院
出处 《心脑血管病防治》 2006年第5期306-308,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
  • 引文网络
  • 相关文献

参考文献5

  • 1Spencer FA,Allegrone J,Goldberg RJ,et al.Association of statin therapy with outcomes of acute coronary syndrome:the GRACE study.Ann Intern Med,2004,140:857-866.
  • 2Schwartz GG,Olsson AG,Ezekowitz MD,et al.Effects of atorvastain on early recurrent ischemic events in acute coronary syndromes:the MIRACLE study.Arandomized Controlled trial.JAMA,2001,285:1711-1718.
  • 3Dupuis J,Tardif JC,Cernacek P,et al.Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes.The RECIFL tial.Circulation,1999,99:3227-3233.
  • 4Plenge JK,Hernandez TL,Weil KM,et al.Simvastatin lowers C-reactive protein within 14 days:an effect independent of low-density Lipoprotein cholesterol reduction.Circulation,2002,106:1447-1452.
  • 5Hernandez-Presa MA,Martin-Ventava JL,Ortego M,et al.Atorvastatin reduces the expression of cyclooxygenase-2 in a rabbit model of atherosclerosis and in cultured vascular smooth muscle cells.Atherosclerosis,2002,160:49-58.

同被引文献6

  • 1Kai H,lkeda H,Yasukawa H,et al.Peripherin blood levels of matrix metalloproteinase-2 and -9 are elevated in patients with acute coronary syndromes[J].J Am Coll Cardial.1998,32:226-228.
  • 2Blann AD,Lip GYH,Beevers BG,et al.Soluble Pselectin in atherosclerosis:A comparison with endothelial cell and platelet markers[J].Thromb Haemost,1997,77:1077.
  • 3ACC/AHA Guidelines for the management of patients With unstable amgina and non-ST-segment elevation myocardial infarction.A report of American college of cardiology/American heart association task force for praction guidelines[J].J Am Coll Cardiol,2000,36:970-1062.
  • 4Spencer FA,Allegrone J,Goldberg RJ,et al.Association of attain therapy with outcomes of acute coronary syndromes:the GRACE study[J].Ann Intern Med,2004,140:857-866.
  • 5Koh KK,Son JW,Ahn JY,et al.Conparative effects of diet and statin on NO bioactivity and matris metalloproteinases in hypercholesterole mic patients with coronary artery disease[J].Arterioscler Thromb Vasc boil,2002,22:19-23.
  • 6Tsiars S,Elisaf M,Mikhailids DP.Early vadcular benefits of statin therapy[J].Curr Med Res Opin.2003,19 (6):540-556.

引证文献1

;
使用帮助 返回顶部