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小儿肾母细胞瘤的发生与p53抑癌基因突变关系的研究 被引量:1

A study of correlation between of occurrence of Wilms' tumor with p53 tumor suppressor gene mutation
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摘要 对14例小儿肾母细胞瘤的p53抑癌基因突变、DNA含量、病理分型及临床分期进行了比较研究。结果表明:①小儿肾母细胞瘤的发生与p53抑癌基因突变有密切关系;②突变与肾母细胞瘤的分化程度有关;③突变见于临床各期;④p53基因突变多见于肾母细胞瘤的二倍体肿瘤。 The correlation of p53 tumor suppressor gene contents of DNA, pathological patterns and clinical stags in 14 cases of Wilms' tumor in children was studied. The results were as follows:①p53 gene mutations in closely related with the occurrence of Wilms' tumor; ②p53 gene mutations is related with degree of differentiation of tumor;③mutations is present in different clinical stages;④p53 gene mutation is often found in diploid Wilms' tumor cell.
出处 《北京医学》 CAS 北大核心 1996年第6期341-343,共3页 Beijing Medical Journal
基金 北京市新星计划资助
关键词 母细胞瘤 P53基因 基因突变 DNA 肾肿瘤 儿童 Wilms' tumor p53 gene Mutations DNA content
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  • 1Hsu I C,Nature,1991年,350卷,6317期,427页

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