摘要
利用利血平诱发的大鼠胃溃疡模型,观察了呋喃唑酮、优降宁和可乐宁的效应。结果表明呋喃唑酮预先给药能完全防止大鼠利血平性胃溃疡的发生,并能对抗利血平耗竭脑内单胺类递质的作用。经典的单胺氧化酶抑制剂优降宁和中枢α_2受体激动剂可乐宁也能有效地阻止大鼠利血甲性胃淡疡的发生。这些结果提示使中枢单胺类递质功能维持在或恢复到正常状态是呋喃唑酮治疗胃溃疡的主要机理。
Effects of furazolidone(Fur), pargyline(Parg) and clonidine(Clo) on reserpine(Res)-induced gastric ulcers and on brain monoamine contents were studied in male Sprague-Dawley rats. It was found that: (1) Fur almost completely and both Parg and Clo significantly prevented the formation of Res-induced gastric ulcers; (2) Fur prevented the exhaustion of brain monoamines induced by Res and(3) Parg increased NA and 5-HT contents but Clo did not. These results suggest that the inhibitory effect of Fur on brain MAO plays an important role in its anti-gastric ulcer mechanism.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第2期128-130,共3页
Academic Journal of Second Military Medical University
关键词
呋喃唑酮
利血平
胃溃疡
单胺
furazolidone
gastric ulcer
monoamines
reserpine
pargyline
clonidine
animal model
