血小板激活因子拮抗剂银杏苦内酯B对烫伤大鼠心血管功能的影响

Effects of PAF Antagonist Ginkgolide B on Cardiovascular Parameters of Thermally Injured Rats

用生物检定法测定揭示:大鼠烫伤后2h,血中PAF含量显著升高,8 h内均显著高于对照组。给大鼠ⅳ标准品PAF引起立即的心血管功能下降,预先给予PAF拈抗剂银杏苦内酯B可以阻断此反应。烫伤后ⅳ银杏苦内酯B的动物,心血管功能维持在较高水甲上。这些结果提示:PAF对烧伤早期心血管功能降低可能起了一定作用。

Platelet-activating factor (PAF), when given to rats (200 ng/kg, iv) induced rapid decrease of BP, LVSP and dp/dt which was antagonized by pretreatment of ginkgolidc B (5 mg/kg.iv). Bioassas showed higher PAF level in the scalded rats (P<0.05 or 0.01) than that in the unscalded control group. Cardiovascular indexes of ginkgolide B-treated rats maintained at higher level than those of the control group. These results suggest that PAF may be partly responsible for the decrease of (?) cardiovascular parameters of the scalded rats.