氯丙嗪与奎硫平对血脂和血糖的影响

The effect of chlorpromazine and quetiapine on serum lipid and glucose

目的:研究氯丙嗪与奎硫平对精神分裂症患者血脂与血糖的影响。方法:130例精神分裂症患者随机分为氯丙嗪组(65例)与奎硫平组(65例),治疗8周。所有患者于治疗前与治疗4、8周测空腹血糖、总胆固醇、三酰甘油和体质量(体重)。结果:氯丙嗪组总胆固醇、三酰甘油、体质量在治疗第4、8周均较治疗前显著升高(P<0.01);奎硫平组三酰甘油、体质量在治疗第4、8周均较治疗前显著升高(P<0.01)。治疗8周后,两组男性患者总胆固醇与空腹血糖较治疗前均显著升高(P<0.01),女性患者三酰甘油与总胆固醇治疗后较治疗前显著升高(P<0.01)。结论:氯丙嗪与奎硫平对血脂和血糖的影响不同,2药对血脂与血糖的影响存在性别差异。

Objective： To study the effect of chlorpromazine and quetiapine on serum lipid and glucose in schizophrenia. Method： 130 patients with schizophrenia were divided into chlorpmmazine group（ n = 65） and quetiapine group（ n = 65） randomly for eight weeks. All the patients were measured fasting blood glucose, eholesteml, triglyceride and body weight before and after treatments for 4, 8 weeks. Results： After four-week and eight-week treatment, the concentrations of eholestorol triglyeeride and body weight ine^a.sed signifieantly in ehlorpmmazine group （P 〈 0.01）.After four-week and eight-week treatment, the eoneentmtions of triglyeeride and body weight increased significantly in quetiapine group（ P 〈 0.01 ）. After eight-week treatment, the concentrations of cholesterol and glueoec increased markedly in male （ P 〈 0.01 ）, and the concentrations of triglyeeride and cholesterol significantly increased in female （ P 〈 0.01 ）. Conclusion： Chlorpromazine and quefiapine differ in their effect on serum lipid and glueoec. Gender differenees exist in effect of ehlorpmmazine and quefiapine on serum lipid and glueoec.