氯氮平对精神分裂症患者体质量、血脂及胰岛素抵抗的影响

Effect of clozapine on weight,blood lipids and insulin resistance in schizophrenic patients

目的:探讨氯氮平对精神分裂症患者体质量(体重)、血脂及胰岛素抵抗的影响。方法:28例氯氮平治疗的精神分裂症住院患者,其中26例完成研究,分别在治疗前和治疗6周末评定阳性与阴性症状量表(PANSS),测量体质量、身高、血糖、血脂、胰岛素及氯氮平药物浓度。结果:与治疗前比较,氯氮平治疗前后体质量指数、三酰甘油水平的增加差异均有显著性(t=-3.181,P=0.004;t=-3.822,P=0.001)。血糖、胆固醇、胰岛素以及胰岛素抵抗等的变化与氯氮平血药物浓度有关。结论:氯氮平可影响精神分裂症患者的体质量指数和血脂水平,氯氮平浓度与胰岛素抵抗有关。

Objective：To explore the effect of clozapine on weight, blood lipid, and insulin resistance in patients with schizophrenia. Method： Twenty-eight schizophrenic inpatients treated with clozapine were investigated and twenty-six cases finished the study, before treatment and the end of sixth week, the patients were determined positive and negative symptom scale （PANSS）, weight, height, glucose, blood lipids, insulin, and concentrations of clozapine. Results：Compared with the baseline levels, the body mass index and triglyeeride level were significantly in- creased （ t = - 3.181, P = 0.004; t = - 3. 822, P = 0.001 ）. The changes of glucose, cholesterol, insulin, insulin resistance were related to concentrations of clozapine. Conclusion： Clozapine has effect on weight and blood lipid and its concentration might be related to insulin resistance.