妊娠晚期孕妇血hCG、HPL及hCG/HPL异常与不良妊娠结局关系的研究

The Level of Human Choriogonadotropin,Human Placental Lactogen in the Third Pregnancy Trimester and the Relationship Between Abnormal hCG/HPL Ratio and Adverse Pregnancy Outcome

目的:通过对妊娠晚期孕妇进行人绒毛膜促性腺激素(hCG)、胎盘泌乳素(HPL)及二者比值的测定,探讨其与不良妊娠结局的关系,以指导临床治疗。方法:随机选取住院分娩孕妇565例,采用放射免疫RIA法进行hCG、HPL检测,并进行统计学处理。结果:早产、胎膜早破及妊娠期高血压综合征患者血清hCG水平明显高于正常妊娠患者(P<0.05,P<0.01),而不良妊娠结局患者与正常妊娠患者HPL检测结果比较无显著差异(P>0.05),但hCG/HPL比较差异非常显著(P<0.01)。结论:hCG可作为预测不良妊娠结局的检测指标之一,监测hCG/HPL可提高高危妊娠的检出率。

Objective：By measuring the Serum levels of Human Choriogonadotropin （hCG） and Human Placental Lactogen（HPL） in the third pregnancy trimester to study the relationship between abnormal hCG/HPL ratio and adverse pregnancy outcome. Methods ： hCG and HPL levels of 565 pregnancy women in the third trimester were measured by Radio Immunoassay. Results ： hCG levels in women with preterm labour, premature rupture of membranes and pregnancy-induced hypertension were higher than that in normal pregnancy outcome （ P 〈 0.05 ） , there was no difference of HPL levels between normal and adverse pregnancy women （ P 〉 0.05 ） , there was significant difference of hCG/HPL ratio between the two groups （ P 〈0.01 ）. Conclusion：hCG level can predict adverse pregnancy outcome,and hCG/HPL ratio can enhance diagnosis of high-risk pregnancy.