初产年龄、产次与骨密度关系的探讨

Study of the relationship among age of first delivery,number of delivery and bone mineral density

目的探讨初产年龄、产次对妇女骨代谢、骨密度影响。方法采用统一问卷表方式调查问卷,早晨8:00～10:00取空腹血和第二次晨尿,尿钙(Ca)、肌酐(Cr)、血碱性磷酸酶(ALP)均采用酶法测定,采用GE公司提供双能X线骨密度仪测定骨密度。结果初产年龄小于25岁组骨形成指标血、ALP骨吸收指标、尿Ca/Cr值高于大于25岁组(P<0.05),产次大于3次组各部位骨密度低于产次3次及以下组(P<0.05),两组骨代谢指标差异无统计学意义。结论女性初产年龄越年轻,产次越多,骨量丢失越多,骨密度越低,越容易发生骨质疏松。

Objective To investigate the relationship of bone mineral density （BMD） ,bone metabolism with age of first delivery and number of delivery. Methods To apply to the same questionnaire and to get empty blood and urine of second time at 8 to 10 in the morning. The urine Ca and Cr were determined by ELISA,and the BMD was by dual energy X-ray abstorptionetry ,provided by GE company.Results Urine ratio of Ca and Cr , value of serum ALP in the ≤25y group was higher than in 〉25y group （P〈0.05）.There is no difference of in BMD in both groups （P〉0.05）. The value of BMD in Le-4,Neck,Total was lower in the group ,whcr, e number of delivery were more than 3, than in 3 or less group （P 〈 0.05） There was no difference of bone metabolism in both groups.Conehtsion The younger first delivery and the more delivery, the more less of bone mineral density.