2[1]Larry WH,George BB,Stan J,et al.Evaluation of the antitumor activity of gemcitabine[J].Cancer Res,1990,50(14) :4417-4422.
3[2]James LA,Ralf G,Earle AW,et al.A Phase Ⅰ clinical,plasma and cellular parmacology study of gemcitabine[ J].J Clin Oncol,1991,9(3) :491-498.
4[3]Boudewijn JM,Braakhuis GA,Jan BV,et al.Preclinical in vivo activity gemcitabine against human head and neck cancer [ J].Cancer Res,1991,51(1) :211-214 .
5[4]James LA.Phase I studies with the novel nucleoside analog gemcitabine[ J].Semin Oncol,1996 10(Suppl 23 ): ,25-31.
6[5]Anderson H,Lund B,Bach F,et al.Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase Ⅱ study[J].J Clin Oncol ,1994,12(9): 1821-1826.
7[6]Paymond PA,Werner RB,Geoffvey F,et al.Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase Ⅱ study[ J ].J Clin Oncol,1994,12(8): 1535-1540.
8[7]Gatzemeier R,Shepherd FA,Chevalier TL,et al.Activity of gemcitabine in patients with non-small-cell lung cancer[ J ].Eur J Cancer,1996,32 ( 1 ): 243 -248.
9[8]Fukuoka M,Takada M,Yokoyama A,et al.Phase Ⅱ study of gemcitabine for non-small-cell lung cancer in Japan [ J ] .Semin Oncol,1998,25 ( Suppl 7 ): 42-46.
10[9]Crino L,Scagliotti G,Marangolo M,et al.Cisplatin-gemcitabine combination in advanced non-small-cell lung cancer: a phase Ⅱ trail[J].J Clin Oncol ,1997,15(1):297-303.
8Potier.The synthesis of navelbine,prototype of a new series of vinb-lastine dervatives[J].Semin Oncal,1989,16(2 suppl 4):2-4.
9Schiler JH,Harrington D,Belani CP,et al.Comparsion of for four chemotherapy regimens for advanced non-small cell lung cancer[J].N Engl J Med,2002,346(2):92-98.
