颅内肿瘤切除术后颅内感染危险因素分析

Analysis on risk factors for intracranial infection after intracranial tumor operation

目的探讨颅内肿瘤切除术后颅内感染的危险因素和预防措施。方法回顾性分析442例颅内肿瘤切除术患者的临床资料。结果442例颅内肿瘤切除术患者发生颅内感染33例,感染率为7.47%。非脑膜瘤手术颅内感染率为10.04%,高于脑膜瘤术后颅内感染率3.83%(P<0.05);手术时间≥4 h者颅内感染率为9.87%,高于手术时间<4 h者颅内感染率4.78%(P<0.05);有脑脊液漏者颅内感染率为15.00%,高于无脑脊液漏者颅内感染率6.28%(P<0.05);引流管留置≥24 h者颅内感染率为11.58%,高于未留置或留置<24 h者颅内感染率5.03%(P<0.05)。结论手术时间≥4 h、引流管留置时间≥24 h、存在脑脊液漏是颅内肿瘤切除术后发生颅内感染的危险因素。

Objective To investigate the risk factors and preventive measures for intracranial infection after excision of intracranial tumor. Methods Clinical data of 442 patients with excision of intracranial tumor were reviewed. Results Thirty-three of 442 patients occurred intracranial infection, infection rate was 7. 47%, the infection rate of non-meningoma operation was 10. 04%, which was higher than that of meningoma operation （3.83%） （ P %0. 05） ; The infection rate in patients with operation time ≥4 hours was 9. 87%, which was higher than that of 〈4 hours （4. 78%） （ P 〈0. 05） ; The infection rate in patients with leakage of cerebrospinal fluid and without leakage of cerebrospinal fluid was 15. 00% and 6.28% respectively （P 〈0. 05）; The infection rate in patients with drainage tube duration ≥24 hours and 〈24 hours was 11.58% and 5. 03% respectively （ P〈0. 05）. Conclusion The main risk factors for post-operative intracranial infection in patients with excision of intracranial tumor were operation time ≥4 hours, drainage tube duration ≥24 and leakage of cerebrospinal fluid.