期刊文献+

人肝细胞癌和癌周肝铜锌超氧物歧化酶免疫组织化学定位观察

Immunohistocheinical Localization of Copper-Zinc Superoxide Dismutase in Human Hepatocellular Carcinoma and Its Surrounding Tissues
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摘要 采用A蛋白-胶体金探针对24例人肝细胞癌和癌周肝进行了铜锌超氧物歧化酶免疫组织化学定位观察。发现22例癌和癌周肝呈现不同程度的阳性反应。癌组织分化程度高的,酶的阳性较强;胞浆致密红染的细胞阳性强,而胞浆疏松或呈空泡状者阳性弱。对癌组织内超氧物歧化酶的意义以及少数细胞核呈阳性反应的问题进行了讨论。 By using protein A-gold labeling probe, copper-zinc superoxide dismutase (Cu-Zn SOD)in paraffin-embedded sections of 24 cases of human hepatocellular carcinoma (HCC) and its surrounding liver tissues was immunolocalizied The experimental results showed that in a good many of HCCs and its surrounding liver tissues, immunostaining of Cu-Zn SOD appeared differently positive, but in 2 cases of grade Ⅱ differentiation, massive pattern of HCC, Cu-Zn SOD immunostaining was negative. In one hepatoma was clear cell carcinoma, and in another one tumor cells followed obvious fatty degenera tioa Two problems that what was significance of Cu-Zn SOD in HCQ and a few cellular nuclei labeled for Cu-Zn SOD are disscussed.
出处 《第二军医大学学报》 CAS CSCD 北大核心 1990年第5期417-420,共4页 Academic Journal of Second Military Medical University
关键词 肝细胞癌 Cu.Zn-SOD 免疫组化 hepatocellular carcinoma immunohistochemistry protein A-gold labeling probe copper-zinc superoxide dismutase
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