2型糖尿病在急性应激反应时血尿酸与C反应蛋白的相关性研究

The Study on the Relationship between CRP and the Level of Serum Uric Acid in Type 2 Diabetes Mellitus Patients with Acute Stress Reaction

目的探讨血尿酸与C反应蛋白(c-reactive protein,CRP)在2型糖尿病急性应激反应时的变化及其相互关系。方法对86例2型糖尿病人(男49例,女37例)合并急性应激病变时的临床资料进行回归分析。结果糖尿病无应激反应组(G3组)CRP为(1.25±0.42)m g/L,而在合并应激反应(G1组)及应激3～5d后(G2组),CRP分别为(3.69±1.92)m g/L和(3.72±1.85)mg/L,两者与G3组比较,差别均有统计学意义(P<0.01),而两者之间比较,无统计学意义。G3组血尿酸水平为(380.78±120.60)μm ol/L,G1组为(385.62±110.70)μmol/L,两组比较无统计学意义。G2组血尿酸水平为(430.00±112.50)μmol/L,与G 1、G 3组比较,差别均有统计学意义(P<0.05)。经Pearson相关分析,G 3组和G 2组CR P与血尿酸水平呈正相关(r=0.589,P<0.05;r=0.526,P<0.05),G1组未观察到两者有相关性。结论CRP和血尿酸是2型糖尿病急性应激反应的危险性敏感指标,而以CRP更为敏感。

Objective To observe the change and the relationship between the CRP and the level of serum uric acid in type 2 diabetes mellitus （T2DM） patients with acute stress. Methods Clinical data of 86 T2DM patients with acute stress reaction were collected including age, course of T2DM, blood pressure, fasting glucose, serum levels of total cholesterol（TC）, triglyceride（TG）, HDL cholesterol （HDL-c）, LDL-cholesterol（LDL-c）, CRP and serum uric acid, assessed the value and the relationship of CRP and the level of serum uric acid. Results CRP was correlated significantly with the level of serum uric acid. CRP was more sensitive than serum uric acid in T2DM patients with acute stress reaction. Conclusion CRP and serum uric acid were more sensitive markers for evaluating acute stress reaction in T2DM patients.