前手性酮的不对称还原(Ⅱ)

Asymmetric Reduction of Prochiral Ketones

综述了前手性酮的不对称还原方法及其近年来的新进展.包括手性唑硼烷类催化剂的应用,使用手性改型氢化铝锂的还原,手性修饰的硼氢化钠或硼氢化钾的应用,具有膦酰胺结构的手性催化剂的应用,手性金属络合物催化氢化不对称还原,不对称相转移催化还原,酶催化不对称还原.

In this review, asymmetric reduction of prochiral ketones and its recent advances have been described, including application of ehiral oxazaborolidine catalysts, reduction by chirally modified lithium aluminum hydride reagents, application of ehirally modified sodium borohydride or potassium borohydride, application of ehiral phosphoramide catalysts, transfer hydrogenation of proehiral ketones catalyzed by ehiral metal complexes, asymmetric reduetion of proehiral ketones by phase-transfer eatalysis, enantioseleetive reduction of ketones with enzyme.