复方大果木姜子软胶囊抗流感病毒作用的体外实验研究

Anti-influenza Effect of Fufang Daguomujizngzi Ruanjiaonang in vitro

目的 对复方大果木姜子软胶囊进行体外抗流感病毒实验研究，开发安全有效的抗流感病毒的中药新药。方法 细胞培养实验方法。结果 复方大果木姜子软胶囊在MDCK细咆中的半数中毒浓度（TC50）为1．248mg·ml^-1；预防组抗流感病毒的半数有效浓度（EC50）为0．117mg·ml^-1；治疗指数（TI）为10．67；感染病毒0—7h后均有明显的抑制FM1在MDCK细胞中增殖的作用。结论 复方大果木姜子软胶囊对流感病毒FM1在MDCK细胞中的增殖具有明显的抑制作用。

Objective To observe the effect of anti - virus by conpound - herbs china momum migao H. W. Li soft capsule, to develop an effective new drug of anti - virus. Methods The cell culture experiment. Results It was found to be a potential inhibitor of influenza FMl virus in a concentration - dependent manner with a TC50 of 1. 248 mg · ml^-1 in MDCK culture. The EC50 was 0. 117 mg· ml^-1 （TI = 10.67） when drug was added for 0-7 hours after virus infection. Conclusion There might be a quantity - effect relationship and it has notable restrain effect.