顶空气相色谱法测定酮苯丙氨酸钙中六种残留溶剂

Determination of Six Residual Solvents in α-Ketophenylalanine Calcium by Gas Chromatography

目的测定酮苯丙氨酸钙中甲醇、丙酮、异丁醛、2-甲基异丁醛、异丁基甲基酮及苯甲醛含量。方法顶空气相色谱法,氢火焰离子化检测器,以甲苯为溶剂,外标法,采用30m×0.32mm涂布厚度5μm的DB-5毛细管柱。结果3批样品中的6种有机溶剂残留均符合规定。结论方法灵敏,简便,精确,重现性好。

Objective： To determinate the contents of residual organic solvents： methanol, acetone, isobutanal, 2-Methylbutylaldehyde, Methyl-iso-butyl ketone, benzaldehyde in a-Ketophenylalanine Calcium by Gas Chromatography. Methods： GC/ FID. The concentration of residual organic solvent was quantified by external standard method. Toluene was used as solvent. Results：The contents of six residual volatile organic solvents in three bathes of samples were complied with the specification requiremens. Conclusions ： The method was proved to be sensitive, simple, rapid, precise and reproducible. It can be a quality control standard for the contents of residual organic solvents of the tested sample.