65岁以上非小细胞肺癌三维适形放射治疗的疗效观察

Therapeutic effect of three dimensional conformal radiotherapy in patients aged 65 years and older with non-small cell lung cancer

背景与目的对于65岁以上无法手术的非小细胞肺癌(NSCLC),三维适形放射治疗是重要的治疗手段之一。本研究的目的旨在分析三维适形放射治疗对这类无法手术的老年NSCLC的临床疗效。方法本组治疗了31例65岁以上无法手术的Ⅱ、Ⅲ期NSCLC,总结分析了治疗的疗效、生存率和放疗反应。结果本组治疗总有效率为87.1%,1年生存率为83.9%,2年生存率为51.6%,3年生存率为25.8%,近期疗效与肿瘤大小有关。急性放射性肺炎发生率为3.2%(1/31),肺纤维化发生率为19.4%(6/31)。结论对无法手术的老年NSCLC患者,三维适形放射治疗是安全、有效的方法,近期疗效满意。

Background and objective Three dimensional conformal radiotherapy is one of the important treatment methods for patients aged 65 and older with inoperable non-small cell lung cancer （NSCLC）. The aim of this study is to evaluate the efficacy of three dimensional conformal radiotherapy in elderly patients with inoperable NSCLC. Methods Thirty-one patients aged 65 and older with stage Ⅱ and Ⅲ NSCLC were treated by three dimensional conformal radiotherapy. Clinical effects, survival rates and pulmonary toxicity were analyzed. Results The overall response rate （CR＋PR） was 87.1% （27/31）. The 1, 2 and 3-year survival rates were 83.9% （26/31）, 51. 6% （16/31）, and 25.8% （8/31） respectively. The relation of treatment efficacy and tumor size was observed. Acute radiation pneumonitis occurred in 3.2% （1/31） of the patients. Radiation pulmonary fibrosis occurred in 19.4%（6/31 ） of the patients. Conclusion Three dimensional conformal radiotherapy is a safe and effective treatment for elderly patients with inoperable NSCLC and has a high survival rate.