姜总酮对实验性血栓形成的影响

EFFECT OF TKG ON PLATELET FUNCTION AND THROMBOSIS

研究观察了生姜提取物姜总酮（ＴｏｔａｌＫｅｔｏｎｅｏｆＧｉｎｇｅｒ，ＴＫＧ）对大鼠颈动脉血栓和小鼠肺血栓形成的影响及急性毒性实验。结果用ＴＫＧ（１０，２０ｍｇ／ｋｇ）可使大鼠颈动脉血流阻塞时间（ＯＴ）明显延长，ＴＫＧ（２０，４０ｍｇ／ｋｇ）可使胶原和肾上腺素形成的诱导剂所致小鼠病死率明显减少，腹腔注射ＴＫＧ的ＬＤ５０及９５％可信限为：５５７．０４ｍｇ／ｋｇ（４３０．９４～７２０．０４ｍｇ／ｋｇ）。

he effects of total ketone of ginger(TKG) on arterial thrombosis in rats and pulmonary thombosis in mice were studied in this paper.The result showed that TKG(20,40mg/kg) can decrease the death rate of mice induced by strong indecer formed by collagen and adrenalin.LD50 is 557.04mg/kg(430.94～720 04mg/kg).The result suggest that TKG has inhabatory effects of thrombosis.