平阳霉素碘化油混合乳剂动脉栓塞在治疗肝血管瘤中的临床应用

Clinical application of pingyangmycin lipiodol emulsion arterial embolization in the treatment of hepatic hemangioma

目的 分析和探讨平阳霉素碘化油混合乳剂（PLE）动脉栓塞在肝血管瘤介入治疗中的临床疗效.方法 运用超液态碘化油＋明胶海绵颗粒和PLE,对我院42例肝血管瘤患者进行动脉栓塞治疗,其中24例运用PLE进行栓塞治疗,运用PLE时其中6例患者追加明胶海绵颗粒进行栓塞,术后2～6个月观察碘油沉积、肿瘤大小变化及并发症的发生.结果 所有病例术前肝动脉造影显示“枝上挂果”“早出晚归”的异常血管湖样改变,栓塞后肿瘤内碘油沉积良好;术后1例出现严重并发症,4例栓塞后无明显效果,其他患者肿瘤均缩小,20例患者肿瘤缩小＞50%.结论 平阳霉素碘化油混合乳剂动脉栓塞治疗肝血管瘤是一种疗效肯定,安全理想的治疗方法.

Objective To analyze and investigate the clinical therapeutic effect of pingyangmycin lipiodol emulsion arterial embolization for hepatic hemangioma. Methods We made use of lipiodol-ultrafluid, gelfoam particles and pingyangmycin lipiodol emulsion to treat 42 patients in our hospital by arterial embolization. Additionally, 6 cases of the treatment with PLE were embolized with gelfoam particles. During the 2--6 months follow-up, we observed the deposit of lipiodol, the change of the tumor diameter and the occurrence of complication after the operation. Results Preoperative liver arterial opacification in all cases showed that multiple abnormal vascular lakes in early arterial phase, known as ＂hanging out on a twig＂ sign and ＂early leaving but late returning＂ sign. After embolization, the lipiodol deposited well in tumors. After operation 1 case appeared severe complications, 4 cases were inefficient, the others were decreased in different degrees and 20 patients＂ tumors reduced over 50%. Conclusion The pingyangmycin lipiodol emulsion arterial embolization is an effective, safe and optimum method to treat hepatic hemangioma.