序贯抗凝治疗短暂性脑缺血发作及进展性卒中58例临床观察

Clinical study of Sequently Anti-coagnlation Therapy of TIA and Progressive Stroke.

目的探讨序贯抗凝在治疗缺血性脑血管病的临床效果。方法收集58例患者,频繁发生的短暂性脑缺血发作(TIA)28例及进展性卒中30例,应用肝素抗凝等治疗后病情仍继续进展的,改用口服华法林抗凝,进行疗效评价。结果痊愈24．1％；显效50％；好转17．3％,无效8．6％；用药前后神经功能缺损程度评分比较P＜0．01有非常显著性差异。结论临床序贯抗凝治疗缺血性脑血管病,治愈、好转率高,后遗症少,是值得临床广泛应用的一种可行的治疗方法。

Objective To study the clinical effect of sequent anti - coagnlation treatment of ischemic cerebral vascicular disease. Methods 28 frequent TIA and 30 progressive ischemic stroke patients were studyed. The patients with progressive stroke were given general anti - coagnlation and other common therapy firstly. Those who got worse clinical symptoms and signs received uarfarin orally. The effects of before and after uarfarin therapy were compared. Results Of all the 58 patients,24.1% patients recovered completely,50% improved obviously,17.3% improved and 8.6% had no effects, before and after takeing medicines the score Comparison about neurological impairment degree has a highly signifient difference （ P 〈 0.01 ）. Conclusions Comparing with general treatment, sequent anti - coagnlation therapy can give patients with ischemic cerebral vascicular disease a higher recovery rate and less sequels. Sequent anti - coagnlation therapy may be widely used clinically.