阻塞性睡眠呼吸暂停低通气综合征与遗传

The Genetics of Obstructive Sleep Apnea-hypopnea Syndrome.

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种发病率高,危险性大的疾病。越来越多的证据表明,它是一种复杂的多基因遗传病,存在着明显的家族聚集现象和遗传倾向,一些与上气道畸形、异常呼吸调控、肥胖、高血压、胰岛素抵抗等有关的基因表型增加了OSAHS的易感性。文章综述了近年来对OSAHS发病机制中有关遗传基因方面的研究进展。

The obstructive sleep apnea - hypopnea syndrome （OSAHS） is considered as a complex genetic disorder with high morbidity and mortality. More and more evidence indicate that it has familial aggregation and genetic predisposition. Some gene phenotypes related to upper airway anomalies, abnormal breathing control, obesity, hypertension and insulin resistance might act to increase susceptibility to OSAHS. This article reviews current knowledge about a genetic approach to the causes and risk factors for sleep apnea.