乙型肝炎免疫球蛋白与乙型肝炎疫苗联合免疫预防围产期乙型肝炎病毒传播

Summary of the Combined Hepatitis B Immunoglobulin and Hepatitis B Vaccine to Prevent the Perinatal Transmission of Hepatitis B

中国是乙型病毒性肝炎(乙肝)高发地区,乙肝病毒(HBV)的感染对人群健康构成严重的威胁。而母婴传播是HBV在中国传播的重要途径。联合使用乙肝免疫球蛋白和乙肝疫苗(HepB)被广泛用于阻断围产期HBV母婴传播。国内外的诸多研究表明,联合免疫的阻断效果要强于单独使用HepB,同时随着流行情况及人群流行病学特征的差异以及免疫剂量和免疫程序不同,联合免疫的效果也会有相应的差异。

China has high endemic in Hepatitis B. infection of Heapatitis B remains great threats to the health of the Public. Perinatal transmission of HBV from carrier mothers to newborns appears to be the most important factor for the high prevalence of HBV infection. Now the combined use of Hepatitis B vaccine and Hepatitis B immunoglobulin are widely recommended in the prevention of HBV perinatal tranmission. The results of worldwide or domestic studies indicate that the combined immunoprophylaxis lead to better and long-term protection against Hepatitis B rather than using Hepatitis B vaccine only, the difference in the endemic situation, the dosage and the schedule would contribute to a different effect of the combined immunization in the same time.