血循环中内皮细胞数量变化意义的初探

Preliminary Approach to the Numeral Alteration of Circulating Endothelial Cells

近年来,国外学者采用定量观察循环血中内皮细胞(Circulating Endothelial Cell,CEC)的方法研究了一些疾病或因素对机体的影响。由于这种方法能结合临床病人研究内皮细胞的数量变化和功能变化,故有一定的临床应用价值。本文综合了国外近几年来分离、计数和鉴定CEC的方法,对65例正常人和65例外科患者的CEC的数量进行了对照观察。目前,国内外尚未见到观察外科患者CEC数量变化的文献报道。 实验结果表明:65例正常人的CEC为1.3±0.7/0.9μl,而65例外科患者的CEC为2.0±0.9/0.9μl,后者较前者有非常显著增多(P<0.001)。其原因尚有待进一步探讨。

The circulating endothelial cells (CEC) of 65 healthy volunteers and 65 patients with surgical wounds are counted respectively. CEC from the patients(2.0 ±0.9/0.9μ1) are more than those of the volunteers (1.3± 0.7/0.9μl, P<0.001). It suggests that the change of CEC count may be useful for the quantitative evaluating the damage of blood vessels of patients with surgical wounds.