高血压病患者红细胞钠离子转运及其对降压的反应

Sodium Ion Transport by Erythrocytes in Hypertensive and Its Response to Antihypertensive Therapy

本文观察了高血压病(EH)患者的红细胞钠离子转运和血浆内源性类洋地黄物质(EDLC)的变化及硝苯啶和哌唑嗪对其影响,结果:EH患者红细胞的钠泵功能和Na^+-K^+内向协同转运明显低于正常,血浆EDLC显著升高,但其与钠泵非平行改变。经降压治疗,EH患者的钠泵和EDLC明显改善。本文对钠离子转运与EH的关系,及降压药物对其作用作了初步探讨。

The transport of sodium ions by erythrocytes and the plasma level of endogenous digitalis-like compound (EDLC) were assessed in 59 patients with essential hypertension before and after the administration of nifedipine and prazosin. 20 normal subjects were studied similarly and served as control. It was found that ( 1 ) EH patients had a pronounced defect of both the active and passive transport of sodium ions by the erythrocytes; ( 2 ) a higher plasma level of EDLC was detected in EH patients as compared with that of the control, but the changes of EDLC and sodium pump were not parallel, (3) after the administration of nifedipine and prazosin, the function of sodium pump was markedly improved and the plasma level of EDLC decreased. In addition, the relationship between the transport of sodium ions by erythrocytes and the pathogenesis of EH, and the effects of antihypertensive agents were discussed.