摘要
本文研究目的是探讨红细胞增多和慢性缺氧对血液流变学和右心室肥大的影响。实验的大鼠分4组:(1)对照组;(2)单纯红细胞增多组:以CoCl_2注射引起大鼠RBC增多;(3)慢性缺氧组:在模拟4000m高度慢性减压47天;(4)慢性减压复合CoCl_2注射组。结果表明慢性缺氧或单纯RBC增多均引起所有切变率下尤其是低切变率下的血液粘滞性增加、右室收缩压增高和右室指数增大;缺氧复合RBC增多上述指标更进一步增加。右室指数与Ht及低切变率时(2.24sec^(-1))血液粘滞性呈明显正相关。以上结果证明RBC增多,在缺氧性右心肥大发生上起重要作用,此外还讨论了RBC增多引起右心肥大的机制。
Effects of chronic hypoxia combined polycythemia on the blood rheology and the right ventricular hypertrophy (RVH) are studied. Experimental rats are divided into 4 groups: 1, control; 2, simple polythemia induced with CoCl2 injection; 3, simple chronic hypoxia, rats are exposed to simulated 4000m high altitude for 47d; 4, chronic hypoxia combined polycythemia produced with CoCl2 injection (experimental condition is the same as group 2 & 3) . All the above parameters further increase in group4 comparing with group 1 or group 2. Linear positive relation regression is seen when RV weight index is plotted against hemocrit or blood viscosity at 2.24 sec shear rate. Polycythemia plays an important role in the pathogenesis of the hypoxic right ventricular hypertrophy.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1990年第4期309-315,共7页
Journal of Third Military Medical University