胃癌单克隆抗体MG7相应抗原在不同型肠化组织中的表达

Expression of Gastric Carcinoma Related Antigen inDifferent Types of Intestinal Metaplasia Definedby Monoclonal Antibody MG7

应用抗人胃癌单克隆抗体MG7及ABC免疫酶标技术,检测了胃癌相关抗原在110例手术切除胃癌标本及343例胃粘膜活检肠化标本的表达。应用粘液组化方法将肠化分为Ⅰ、Ⅱ和Ⅲ型。110例胃癌中,有92例(83.6％)MG7染色阳性。在不同类型肠化中,Ⅲ型肠化中MG7相应抗原的阳性率(46.7％)显著高于Ⅱ型(25.6％)和Ⅰ型肠化(18.6％)(P<0.01)。结果表明,Ⅲ型肠化与胃癌的发生有密切关系,应作为癌前病变对待;单克隆抗体MG7对筛选肠化患者中胃癌高危病例可能有重要价值。

The expression of gastric carcinoma related antigen was observed in 110 gastrectomy specimens with gastric carcinoma and 343 biopsy specimens with intestinal metaplasia by ABC immunohistochemical staining with MG 7 , a monoclonal antibody against human gastric carcinoma. Intestinal metaplasia was classified into types I, II and III by histochemical mucin stainings. Among the 110 cases of gastric carcinomas, 92 (83.6%) showed the positive reaction for MG 7 related antigen. In different types of intestinal metaplasia, type III (46.7%) exhibited a significantly higher positive rate for MG 7 related antigen than type II (25.6%) and type I (18.6%) (P<0.01) . Our results indicate that type III intestinal metaplasia is closely related to the histogenesis of gastric carcinoma and should be considered as precancerous lesion and that MG 7 monoclonal antibody may be useful in screening for the risk of gastric carcinoma in patients with intestinal metaplasia.